Hypercortisolism (Cushing Syndrome)

Overview

4.5 out of 5 (14 Reviews)

Credits

1.50

Pharmacology Credits

0.5

Post-Assessment Questions

10

Start Date

1 Sep 2023

Last Review Date

28 Nov 2025

Expiration Date

31 Aug 2026

Estimated Time To Finish

90 Minutes


Unlimited Nurse Practitioner CE

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Activity Description

Hypercortisolism is a clinical state caused by prolonged exposure to excess cortisol or related glucocorticoids from endogenous or exogenous sources. Sustained hypercortisolism leads to characteristic clinical manifestations collectively known as Cushing syndrome. The condition’s complexity arises from its wide spectrum of causes, including iatrogenic glucocorticoid use, pituitary adenomas, adrenal tumors, and ectopic adrenocorticotropic hormone (ACTH) production. This course explores the accurate diagnosis of this condition, which demands a high index of clinical suspicion, comprehensive history-taking, physical examination, and confirmatory biochemical testing, given presentations that range from overt Cushing syndrome to subclinical or pseudocushing states. The timely management of hypercortisolism, crucial to reducing associated cardiovascular, metabolic, musculoskeletal, and psychiatric complications, is also discussed.

This activity equips clinicians with advanced knowledge to enhance diagnostic accuracy and evidence-based management of hypercortisolism. Participants will learn to differentiate ACTH-dependent from ACTH-independent etiologies, interpret dynamic testing results, and select appropriate imaging modalities. This activity for healthcare professionals is designed to enhance the learner's competence in identifying hypercortisolism, performing the recommended evaluation, and implementing an appropriate interprofessional approach to manage this condition, optimizing patient outcomes, mitigating comorbidities, and reducing morbidity and mortality associated with delayed or missed diagnoses of hypercortisolism.


Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the clinical features associated with hypercortisolism to improve early recognition.

  • Evaluate the diagnostic algorithms for hypercortisolism.

  • Implement current evidence-based treatment for hypercortisolism.

  • Develop interprofessional team approaches by integrating various clinical specialists to manage hypercortisolism and improve outcomes.

  • Outline the pharmacologic therapy as it applies to Hypercortisolism (Cushing Syndrome)

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Nurse Practitioners: StatPearls designates this activity for 1.50 ANCC contact hour(s), which includes 0.5 hour(s) of pharmacology. NPs should only claim credit commensurate with the extent of their participation in the activity.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

mikaela v. on 8/16/2021

Mary Y. on 2/20/2022

Karl S. on 3/28/2023

Kylee G. on 8/10/2023

Mary Y. on 8/11/2023

Rita O. on 9/22/2023

Kathleen on 10/13/2023

Jacquelyn F. on 6/7/2024

Sandra B. on 2/22/2025

Manuel M. on 3/7/2025

Mary Y. on 9/26/2025

Nancy M. on 5/1/2026

Deborah Z. on 7/25/2026

ABDALLAH K. on 6/30/2026

Unlimited Nurse Practitioner CE

Stay up to date on the latest medical knowledge with 6280 CE activities. In these online self-assessment activities, read our reference articles and test your knowledge with more than 7492.5 hours of CE.

Single Activity

Take this single activity

$73.50 1 activity

6 Month Unlimited Nurse Practitioner CE

Access to all the Unlimited Nurse Practitioner CE activities in all specialties.

$379 per half year per user

1 Year Unlimited Nurse Practitioner CE

Access to all the Unlimited Nurse Practitioner CE activities in all specialties.

$579 per 1 year per user